Glyphs in Diablo 4 provide significant bonuses to skills and playstyles. With the right combination of major and minor glyphs, players can push their damage potential to new heights. In this guide, we'll break down the most damaging glyph choices across all classes to help you optimize damage on your builds.

Barbarian Glyphs

For maximum damage on Barbarian, focus glyphs that improve Whirlwind, Seismic Slam, or Frenzy. Popular choices include:

Mixing damage-increasing glyphs with those reducing cooldowns or resource costs also further optimizes playstyle synergy output overall. Don't forget to buy Diablo 4 gold for rerolling glyphs as needed to acquire the most beneficial combinations.

Crusader Glyphs

For a single target burst with the Crusader, focus glyphs that empower Blessed Hammer, Phalanx, or Flying Smite. Top choices include:

• Major Glyph of Retribution - Blessed Hammer deals 20-30% more damage per hammer
• Major Glyph of Hammer Swing - Increases Blessed Hammer damage by an additional 20-30%
• Major Glyph of Phalanx Brother - Each Phalanx clone increases your damage by 15-25%

Maximizing damage across multiple skills pays high dividends, so glyph choices should align with your intended playstyle focus and synergies whenever possible.

Monk Glyphs

Explosive damage potential comes from glyphs bolstering Seven-Sided Strike, Mystic Allies, or Wave of Light for Monks. Choice picks include:

• Major Glyph of the SSS - Seven-Sided Strike deals an additional 20-30% damage per strike
• Major Glyph of the Red - Mystic Ally summons do 15-25% more damage
• Major Glyph of Solar Prism - Wave of Light explosions damage increased by 15-25%

Monks benefit greatly from glyphs amplifying multiple damage types across various skills for unrelenting output across diverse situations.

Demon Hunter Glyphs

For maximum single-target damage as a Demon Hunter, key glyphs enhance Multishot, Cluster Arrow, or Impale abilities. Top options:

• Major Glyph of the Barrage - Multishot deals an extra 15-25% damage to the first 5 enemies hit
• Major Glyph of Cluster Bombs - Cluster Arrow rockets deal 20-30% more damage
• Major Glyph of Stab Wound - Impale leaves a wound that increases damage taken by 10-15% for 5 seconds

Combining damage over time effects with direct multiplier glyphs compounds overall damage output substantially on Demons and buy Diablo 4 gold.

Necromancer Glyphs

For maximum damage potential as a Necromancer, prioritize glyphs that empower Corpse Lance, Skeletal Mage, or Simulacrums. Recommended choices:

• Major Glyph of Crystal Shards - Corpse Lance projectiles deal an extra 15-25% damage
• Major Glyph of Frosty Touch - Skeletal Mages' cold damage increases by 20-30%
• Major Glyph of Simulacrum Summons - Using Simulacrum raises all damage by 10-15% for 10 seconds

Necromancers scaling multiple minions alongside direct spells gain exceptional offensive flexibility through complementary glyphs.

Wizard Glyphs

For maximum magic damage potential as a Wizard, prioritize glyphs that enhance Disintegrate, Meteor Shower, or Arcane Orb abilities. Top picks include:

• Major Glyph of Beam Strength - Disintegrate deals an extra 15-25% damage to all targets hit
• Major Glyph of Meteor Madness - Meteor Shower hits do 20-30% more damage
• Major Glyph of Orbital Bombardment - Arcane Orb explosions increase damage by 15-25%

Wizards benefit immensely through direct damage multiplier glyphs focusing burst abilities overall.

Sorceress Glyphs

To maximize elemental damage as a Sorceress, prioritize glyphs augmenting Frozen Orb, Lightning skills, or Fire skills respectively. Recommended options:

Versatility across damage types allows Sorceresses to apply devastating force against any threats.

Maximize Glyph Bonuses

stacking as many relevant major and minor damage-increasing glyphs as possible yields tremendous scaling benefits. Prioritize these force multipliers before any survivability or utility glyphs for maximum returns on specialization.

Don't forget glyphs granted from legendary items and endgame content as well. Accounting for all sources cement builds at their absolute highest baseline potential output.

Reroll Glyphs Strategically

The Kanai's Cube recipe allows targeted rerolling of unused damage glyphs into preferred choices over time. Focus on investing resources intelligently hitting optimal multipliers securing multiplicative builds.

Pair rerolling with D4 gold for quick reroll access accelerating optimized setups tremendously, especially early each season